The Dutchman is likely to still be without Kobbie Mainoo and Harry Maguire for the visit of Chelsea with the pair still recovering from respective thigh and knee injuries.
Shaw has not played for his club since February and with Tyrell Malacia also still working his way back towards full fitness after his extended lay-off, van Nistelrooy is likely to remain without a recognised left-back option.
United are still to confirm the extent of Antony’s injury after he was stretchered off with what was reported to be an ankle sprain against Fenerbahce last week.
Leny Yoro meanwhile continues to step up his return in training with hope he can make return to action at some point in November.
Chelsea meanwhile head into the weekend with a relatively clean bill of health.
Jadon Sancho will be ineligible to face his parent club – but having been hooked at the break against Liverpool and left on the bench against Newcastle United last time out in the league, his place in the starting XI suddenly looks very uncertain.
Pedro Neto joined that otherwise settled attacking unit last weekend and is in line to keep his place in registering an assist in that 2-1 win.
As has become the norm, Enzo Maresca made wholesale changes midweek as the Blues crashed out of the Carabao Cup against Newcastle as part of their double-header against the Magpies, making 11 changes to the side that beat the same opposition at the weekend.
There was some concern for Wesley Fofana last weekend after he went down with discomfort in his knee – something Maresca believes will be an issue for the rest of his career after missing a year of action with a ruptured anterior cruciate ligament.
But the former Leicester City star is expected to return to the side this weekend with Reece James hoping for his third successive start in the league after putting his latest injury problems behind him.